Mitchell P Fink Selected Research

Ringer's ethyl pyruvate

11/2003	Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice.
5/2003	Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis.
12/2002	Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock.
6/2002	Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats.
3/2002	Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution.

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Mitchell P Fink Research Topics

Disease

37	Sepsis (Septicemia) 10/2014 - 01/2002
33	Hemorrhagic Shock 01/2014 - 03/2002
26	Inflammation (Inflammations) 11/2016 - 09/2002
15	Critical Illness (Critically Ill) 03/2017 - 03/2002
14	Endotoxemia 09/2009 - 09/2002
10	Ischemia 11/2016 - 03/2002
10	Wounds and Injuries (Trauma) 10/2011 - 08/2003
8	Necrosis 12/2012 - 01/2003
7	Hypoxia (Hypoxemia) 09/2007 - 05/2002
6	Reperfusion Injury 06/2009 - 05/2003
6	Mesenteric Ischemia 06/2009 - 06/2002
6	Infections 08/2007 - 09/2002
5	Shock 03/2017 - 12/2002
5	Hemorrhage 09/2007 - 08/2004
4	Pancreatitis 01/2011 - 07/2004
4	Peritonitis 04/2007 - 01/2003
3	Septic Shock (Toxic Shock Syndrome) 02/2015 - 08/2005
3	Burns 01/2011 - 05/2003
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 04/2008 - 02/2002
3	Multiple Organ Failure (MODS) 02/2004 - 03/2002
3	Anemia 01/2004 - 08/2003
2	Stroke (Strokes) 01/2011 - 04/2008
2	Acute Necrotizing Pancreatitis 05/2009 - 07/2004
2	Chronic Disease (Chronic Diseases) 09/2007 - 12/2003
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2007 - 03/2002
2	Ileus 12/2006 - 09/2005
1	Hypotension (Low Blood Pressure) 03/2017
1	Paralysis (Palsy) 11/2016
1	Heart Failure 02/2015
1	Cardiogenic Shock 02/2015
1	Staphylococcal Pneumonia 03/2014
1	Disseminated Intravascular Coagulation 09/2013

Drug/Important Bio-Agent (IBA)

29	ethyl pyruvateIBA 11/2016 - 03/2002
16	CytokinesIBA 12/2012 - 05/2002
14	HMGB1 Protein (HMG1)IBA 03/2014 - 09/2002
14	SolutionsIBA 03/2009 - 03/2002
8	Pyruvic Acid (Pyruvate)IBA 07/2010 - 03/2002
8	LipopolysaccharidesIBA 08/2009 - 12/2002
8	Proteins (Proteins, Gene)FDA Link 09/2007 - 01/2004
7	NF-kappa B (NF-kB)IBA 08/2009 - 09/2003
6	CalciumIBA 11/2016 - 06/2002
6	DNA (Deoxyribonucleic Acid)IBA 12/2006 - 07/2002
6	Oxygen (Dioxygen)IBA 08/2004 - 01/2002
5	Interleukin-6 (Interleukin 6)IBA 11/2016 - 09/2003
5	Pharmaceutical PreparationsIBA 10/2014 - 01/2005
5	Ringer's LactateIBA 12/2006 - 01/2003
5	salicylhydroxamic acid (SHAM)IBA 12/2006 - 11/2003
5	SaltsIBA 11/2003 - 06/2002
5	Ringer's ethyl pyruvateIBA 11/2003 - 03/2002
4	AntioxidantsIBA 11/2016 - 06/2002
4	Alanine Transaminase (SGPT)IBA 05/2009 - 11/2003
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2009 - 09/2002
4	PolymersIBA 03/2009 - 01/2004
4	EstersIBA 04/2008 - 01/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2008 - 02/2002
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2005 - 12/2002
3	Erythropoietin FDA Link 12/2012 - 12/2002
3	Messenger RNA (mRNA)IBA 05/2009 - 03/2003
3	Transcription Factors (Transcription Factor)IBA 01/2007 - 03/2003
3	Immunoglobulin G (IgG)IBA 04/2006 - 11/2003
2	Nitric Oxide Synthase (NO Synthase)IBA 06/2014 - 02/2004
2	IronIBA 12/2012 - 12/2003
2	Adenosine Triphosphate (ATP)IBA 01/2011 - 04/2003
2	AnionsIBA 07/2010 - 04/2008
2	LipidsIBA 03/2010 - 09/2007
2	PPAR gammaIBA 06/2009 - 02/2004
2	EthionineIBA 05/2009 - 07/2004
2	Choline (Choline Chloride)IBA 05/2009 - 07/2004
2	CeruletideIBA 05/2009 - 07/2004
2	Reactive Nitrogen SpeciesIBA 01/2008 - 02/2002
2	Gramicidin (Gramicidin A)FDA LinkGeneric 01/2008 - 09/2007
2	TEMPOIBA 09/2007 - 02/2007
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2007 - 01/2004
2	Peptides (Polypeptides)IBA 09/2007 - 11/2003
2	XJB-5-131IBA 09/2007 - 09/2007
2	drotrecogin alfa activated (Xigris)FDA Link 01/2007 - 08/2005
2	Neutralizing AntibodiesIBA 01/2007 - 04/2006
2	AntibodiesIBA 04/2006 - 01/2003
2	NitratesIBA 09/2005 - 12/2002
2	NitritesIBA 09/2005 - 12/2002
2	BilirubinIBA 10/2004 - 01/2004
2	Saline SolutionIBA 08/2004 - 11/2003
2	fluorescein isothiocyanate dextranIBA 03/2004 - 11/2003
2	NAD (NADH)IBA 12/2002 - 05/2002
2	EnzymesIBA 12/2002 - 05/2002
1	CatecholaminesIBA 03/2017
1	Angiotensin IIIBA 03/2017
1	Chemotactic FactorsIBA 11/2016
1	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 11/2016
1	6- (beta- pyridyl)- 3- hydroxy- pyrazol(3,4b)pyridineIBA 01/2014
1	4-hydroxyphenylpyruvic acidIBA 01/2014
1	ThrombomodulinIBA 09/2013

Therapy/Procedure

21	Resuscitation 10/2011 - 03/2002
7	Critical Care (Surgical Intensive Care) 04/2012 - 04/2003
6	Therapeutics 03/2017 - 01/2004
4	Treatment Delay 09/2007 - 12/2002
2	Ligation 04/2007 - 01/2007
2	Transplantation 01/2005 - 04/2004
2	Blood Transfusion (Blood Transfusions) 01/2004 - 08/2003
1	Extracorporeal Membrane Oxygenation 02/2015